科技部專題研究計畫主持人
MOST-107-2410-H-418-001-SS2
雙向光譜障礙症(Bipolar spectrum disorders)和飲食障礙症在臨床族群的共病研究
Comorbidity of bipolar spectrum disorders and eating disorders in clinical population
科技部
Ministry of Science and Technology
醫療財團法人徐元智先生醫藥基金會亞東紀念醫院
Far Eastern Memorial Hospital
曾美智
Mei-Chih Tseng
衛生福利部雙和醫院
Taipei Medical University-Shuang Ho Hospital,Ministry of Health and Welfare
曾美智
醫師
0955925525
mctseng@ntu.edu.tw
計畫執行期間起:2018-08-01
計畫執行期間迄:2020-07-31
2018-10-01
2020-06-27
精神科門診和精神科住院病人
1
001,004
01
雙向光譜障礙症;飲食障礙症;氣質;暴食症
binge-eating;affective temperament;hypomania;depression;corrrelates;comorbidity
本研究的目的是調查臨床族群,雙向光譜障礙症和飲食障礙症共病症的盛行率和相關因子,尤其是氣質(temperament)對共病症的影響。本研究將以兩年時間在兩個族群,精神科門診和精神科住院病人,進行收案。 門診部分,以兩階段方式找出雙向光譜障礙症個案。第一步以躁鬱光譜診斷量表(Bipolar Spectrum Diagnostic Scale)問卷進行個案篩選,納入條件為16-65歲 ,可配合研究問卷填寫,具中文聽寫理解能力,且不能合併智能障礙,器質性精神疾病和嚴重身體疾病者。預計篩選1000位門診病人。躁鬱光譜診斷量表( 10分)和有明顯躁症症狀者,將邀請參加第二階段的診斷性面談,以建立DSM-5情感障礙症是雙向障礙症的躁症發作、輕躁症發作、鬱症發作、或重鬱症合併混合特徵,以及建立是否有飲食障礙症的共病診斷。受試者需同時完成幾份自填量表,包括SCOFF,Alcohol Use Disorder Identification Test,情緒障礙症問卷(Mood Disorder Questionnaire) ,簡版氣質評估量表(Short version of Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego-Auto-questionnaire),簡短症狀量表(Brief Symptom Rating Scale),飲食障礙檢查問卷 (Eating Disorder Examination-Questionnaire),衝動量表(Barratt Impulsiveness Scale),和席漢功能障礙量表(Sheehan Disability Scale)。同時蒐集雙向障礙症發生年齡,病程,和自殺史。 可獲得住院資料下,住院病人選擇符合DSM-5情感障礙症的診斷個案。在住院症狀較穩定後再進行面談和問卷填寫如上。個案收入條件和排除條件如門診病人。資料分析分成躁鬱光譜障礙症合併飲食障礙症和單獨只有躁鬱光譜障礙症進行分析。
This study aims to investigate the prevalence and correlates of bipolar spectrum disorders (BSD) with comorbid eating disorder in clinical populations. This research project recruits both psychiatric outpatients and inpatients at a medical center. We recruit study participants at the psychiatric outpatient setting at a medical center (n = 1000). All participants need to have good comprehension to both spoken and written traditional Chinese, absence of organic mental conditions, mental retardation, psychotic conditions, and severe physical conditions, and age 16 through 65 years. They will be invited to compete a questionnaire, Bipolar Spectrum Diagnostic Scale (BSDS) at the first stage. Patients with a BSDS score of 10 and above as well as those with prominent manic symptoms will be invited to complete structured interviews for establishment of mood disorders and eating disorders according to the DSM-5 criteria at the 2nd stage. They are also asked to complete several questionnaires assessing mania, depression, general psychopathology, eating, alcohol drinking, affective temperament, impulsivity, as well as disability level. We will start to recruit psychiatric inpatients with BSD (bipolar I and II disorders, major depressive disorder with mixed features, or cyclothymic disorder), aged 16 through 65 years with the same inclusion criteria half year later after the psychometric properties of the BSDS and the study procedure have been well established. All participants will receive diagnostic interviews and complete the same self-administered questionnaires as psychiatric outpatients described above. The percentage of BSD and co-occurring rate of BSD and eating disorder in psychiatric outpatients are estimated by descriptive analysis. Analysis one is to compare BSD and non-BSDS subgroups using eating disorder diagnosis, clinical information and all measures. Analysis two is to compare recent episode, affective temperament, and other assessments between BSD with eating disorder group and BSD-only group. We use independent-t test for continuous variables and Pearson\'s Chi-square test for categorical variables. To identify predictors of comorbid condition, we conducted logistic regression analysis.
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